Athlete training — StackProtocol performance supplement science

Performance Supplement Science

Build the stack that actually works.

Rigorous, citation-backed protocols for cognitive performance, sleep depth, testosterone, longevity, and recovery. No guesswork. No hype.

Browse Protocols Free Weekly Digest

101+

Science Guides

100%

Peer-Cited

6

Stack Categories

Free

Always

CREATINE — Strength + Cognition MAGNESIUM L-THREONATE — Sleep + Memory LION'S MANE — NGF + Neurogenesis ASHWAGANDHA KSM-66 — Cortisol Reduction BERBERINE — AMPK Activation L-THEANINE + CAFFEINE — Cognitive Synergy CoQ10 UBIQUINOL — Mitochondrial Energy OMEGA-3 — DHA + EPA Protocol CREATINE — Strength + Cognition MAGNESIUM L-THREONATE — Sleep + Memory LION'S MANE — NGF + Neurogenesis ASHWAGANDHA KSM-66 — Cortisol Reduction BERBERINE — AMPK Activation L-THEANINE + CAFFEINE — Cognitive Synergy CoQ10 UBIQUINOL — Mitochondrial Energy OMEGA-3 — DHA + EPA Protocol

Featured Protocols

Supplement stack protocol

The Cognitive Enhancement Protocol: L-Theanine, Caffeine & Lion's Mane

How these three compounds stack for sustained mental output without the crash.

Sleep stack protocol

Sleep Stack: Magnesium Glycinate, L-Theanine & Ashwagandha

Research lab science

Recovery Stack: Creatine, NMN & Omega-3 — The Complete Guide

All 101+ Protocols

101 guides

Effect Size vs. P-Value: How to Tell Whether a Supplement Study Means Anything

Creatine Gummies vs Powder: Dose Accuracy, Stability & Real Cost

L-Citrulline vs Citrulline Malate: The Dose Arithmetic Labels Hide

Caffeine + L-Theanine: The Cognitive Synergy Stack

L-Theanine & Caffeine: Focus, Anxiety & Alpha Wave Effects

L-Theanine Caffeine Focus: Dosing & Timing Protocol

Lion's Mane Mushroom: NGF, Neurogenesis & Cognitive Enhancement

Lion's Mane: Hericenones, Erinacines & the Mori 2009 RCT

Lion's Mane: Hericium Erinaceus — Brain & Nerve Growth Science

Creatine for Brain: Cognitive Performance & Mental Fatigue

Ashwagandha Sleep Stack: Timing, Dosing & Cortisol Reduction

Best Magnesium for Sleep: Glycinate vs. L-Threonate

Ashwagandha for Sleep: Cortisol, Anxiety & Adaptogen Mechanism

Ashwagandha KSM-66: Cortisol Reduction & Testosterone Optimization

KSM-66 vs Sensoril: HPA Axis, Testosterone & Thyroid Effects

KSM-66 vs Sensoril Ashwagandha: Full Comparison

Ashwagandha & Testosterone: Chandrasekhar 2012 RCT Breakdown

Creatine for Longevity: Muscle Preservation, Brain & Aging

CoQ10 Ubiquinol: Mitochondria, Statin Depletion & Heart Health

CoQ10 Ubiquinol vs Ubiquinone: Which Form for Longevity?

Alpha Lipoic Acid: Universal Antioxidant & Insulin Sensitivity

Best Omega-3 Fish Oil: EPA, DHA Dosing & Anti-Inflammation

Berberine: AMPK Activation, Glucose Metabolism & Metformin Comparison

Beta-Alanine: Carnosine Buffering & Exercise Performance

Creatine vs Beta-Alanine: Which to Stack for Performance?

Creatine Monohydrate: Phosphocreatine, Strength & Cognitive Output

Creatine Monohydrate vs HCL: What the Evidence Actually Says

Creatine Monohydrate: The Complete Recovery & Muscle Science Guide

Collagen Peptides: Joint, Skin & Connective Tissue Recovery

CoQ10 Ubiquinol for Recovery: Mitochondrial Energy Production

ALCAR (Acetyl-L-Carnitine): Mitochondria, Cardiovascular & Recovery

Whey vs Plant Protein: Pea & Soy Compared for Muscle Building

Ashwagandha: The Adaptogen Science Complete Guide

Ashwagandha Withanolides: Cortisol, Stress & Adaptogenic Mechanism

Ashwagandha KSM-66: HPA Axis & Stress Response — Science Deep Dive

Ashwagandha for Anxiety & Cortisol: Clinical Evidence Review

Adaptogens Overview: What the Science Says in 2026

B Vitamins: B12, Folate & B6 — Energy & Methylation Stack

Iodine: Thyroid Function, Deficiency & Supplementation Science

Iron Bioavailability: Heme vs Non-Heme & Ferritin Protocol

Iron Deficiency: Symptoms, Ferritin Testing & Supplementation

Iron Absorption: What Blocks It & How to Optimize

Berberine vs Metformin: AMPK, Glucose & Gut Microbiome

Berberine AMPK & Yin 2008 Study: Glucose Transporter Mechanism

Curcumin + Piperine: Bioavailability, NF-kB & Inflammation

R-ALA: Universal Antioxidant & Diabetic Neuropathy — Ziegler & ALADIN Studies

Alpha Lipoic Acid: Mitochondria, Antioxidant & Insulin Sensitivity

Creatine: Comprehensive Muscle + Brain Science Guide

Creatine: Greenhaff 1994 & Rae 2003 — Phosphocreatine & Cognition Studies

Creatine Loading vs Maintenance: Brain Creatine & Cognitive Function

Creatine for Strength & Cognition: Dual-Purpose Protocol

Creatine ATP: Muscle & Brain Performance — How It Works

Creatine Monohydrate Guide: Dosing, Loading & Timing

Creatine vs Beta-Alanine: Science-Based Stack Decision Guide

CoQ10 Ubiquinol: Complete Guide to Dosing & Bioavailability

CoQ10 & Mitochondrial Energy: What the Evidence Supports

CoQ10 & Statins: Mortensen Heart Failure Study — Clinical Evidence

Collagen Peptides: Skin, Joint & Gut Health Science

Berberine for Blood Sugar: AMPK & Metformin Comparison

Berberine: The Complete Guide to Dosing & Mechanisms

Berberine vs Metformin: Full Clinical Comparison

Berberine vs Metformin for Blood Sugar: 2024 Evidence

AG1 vs Bloom Greens: Which All-in-One Stack Wins?

Berberine for Blood Sugar: Mechanism, Dose & Protocol

Lion's Mane for Brain Health: NGF, BDNF & Memory

Lion's Mane Mushroom: Complete Supplement Guide

Hericium Erinaceus: NGF, BDNF & Neurogenesis — Full Breakdown

Ashwagandha KSM-66: Cortisol, Stress & Anxiety Protocol

Ashwagandha & Cortisol: Stress Reduction Mechanism & Dosing

Ashwagandha KSM-66: Complete Dosing & Protocol Guide

Ashwagandha KSM-66 for Stress & Anxiety: Evidence Review

Rhodiola Rosea vs Panax Ginseng: Which Adaptogen Fights Fatigue?

Iron & Ferritin: Testing, Optimal Levels & Supplementation

Does Bacopa Monnieri Work for Memory and Focus?

Does Tongkat Ali Boost Testosterone?

Glucosamine Chondroitin vs Collagen for Joint Pain

Best Pre-Workout Supplements: The Doses That Actually Work

LMNT vs Liquid IV: Which Electrolyte Mix Is Actually Worth It?

Shilajit vs Tongkat Ali: Which Has Better Evidence?

Ginkgo Biloba vs Bacopa Monnieri: Which Nootropic Actually Improves Memory?

Whey Protein Isolate vs Concentrate: Which One Should You Actually Buy?

Printable Supplement Log: How to Track Supplements (and Run a 30-Day Audit)

Buyer's guides

Before you buy, read the evidence.

Independent guides graded by what the trials show, including the categories we tell you to skip. Some links are affiliate links; see our affiliate disclosure.

Thorne Review Transparent Labs vs Momentous vs Thorne (2026) Transparent Labs Review Momentous Supplements Review (2026) Best Third-Party Tested Supplement Brands The Beginner Supplement Stack for a New Year at the Gym Best Protein Powders for Fat Loss Best Pre-Workout for Beginners and Anyone Returning to the Gym Best Home Gym Starter Kit for 2027 Best Supplement Gifts for Gym-Goers Creatine Black Friday Deals Best Winter Immune Stack Best Sleep Stack for Travel Best Cold Plunge Tubs & Ice Baths Best Infrared Sauna Blankets Best Red Light Therapy Panels Best Water Filters for Heavy Metals Best Third-Party Tested Protein Powders Best VO2 Max & Fitness Testing Devices Best Velocity-Based Training Devices Best Home Blood Pressure Monitors

Stop guessing at your stack

The Stack Protocol

evidence-based supplement stacks for energy, focus, sleep, and longevity — exact doses, exact timing, and an honest list of what to skip.

Get the Stack Protocol → $19 or get all 4 health books for $49

A resource for your family

Scam calls targeting older adults are at record levels — the FBI logged $7.75 billion in reported losses from adults 60+ in 2025. Our free, no-signup guides show families exactly how the calls work — and the four rules that stop them.

Visit Scam-Proof Your Parents →

As an Amazon Associate, StackProtocol earns from qualifying purchases made through links on this page. This does not affect the price you pay.